Gene Details:

• Gene ID: AT2G32710
• Gene Symbol: ACK2, ICK7, KRP4
• Gene Name: CYCLIN-DEPENDENT KINASE INHIBITOR 2, INTERACTORS OF CDC2 KINASE 7, KIP-RELATED PROTEIN 4
• Description: Cyclin-dependent kinase inhibitor family protein;(source:Araport11)
• TAIR Accession: locus:2046427
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G32710.1     AT2G32710.2

Plant Ontology Annotations:

• PO:0000017  — vascular leaf primordium — leaf primordium (exact), portion of vascular leaf primordium tissue (exact), primordio de hoja (Spanish, exact), vascular leaf primordia (exact, plural), 葉原基 (Japanese, exact)
• PO:0000225  — peripheral zone — zona periférica (Spanish, exact), 周辺帯 (Japanese, exact), peripheral meristem (related)
• PO:0025276  — shoot procambium — procambio del epiblasto (Spanish, exact), シュート前形成層 (Japanese, exact)
• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0004861  — enables — cyclin-dependent protein serine/threonine kinase inhibitor activity
• GO:0005634  — located in — nucleus
• GO:0045786  — acts upstream of or within — negative regulation of cell cycle
• GO:0005737  — located in — cytoplasm
• GO:0030332  — enables — cyclin binding

Function-related keywords:

• vascular leaf primordium ,  peripheral zone ,  shoot procambium ,  shoot axis apex ,  root ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  collective leaf structure ,  pollen

Literature:

• Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis.   DOI:  10.1105/tpc.010087 ;  PMID:  11449057
• Genome-wide analysis of core cell cycle genes in Arabidopsis.   DOI:  10.1105/tpc.010445 ;  PMID:  11971144
• Transcriptional regulation of secondary growth in Arabidopsis thaliana.   DOI:  10.1093/jxb/erg304 ;  PMID:  14585825
• Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana.   DOI:  10.1093/aob/mch077 ;  PMID:  15037450
• Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.   DOI:  10.1016/j.febslet.2005.12.018 ;  PMID:  16376885
• A membrane-bound NAC transcription factor regulates cell division in Arabidopsis.   DOI:  10.1105/tpc.106.043018 ;  PMID:  17098812
• Autonomy of cell proliferation and developmental programs during Arabidopsis aboveground organ morphogenesis.   DOI:  10.1016/j.ydbio.2006.12.049 ;  PMID:  17258192
• Arabidopsis cyclin-dependent kinase inhibitors are nuclear-localized and show different localization patterns within the nucleoplasm.   DOI:  10.1007/s00299-006-0294-3 ;  PMID:  17253089
• The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.   DOI:  10.1242/dev.020743 ;  PMID:  18434413
• Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis.   DOI:  10.1105/tpc.108.059741 ;  PMID:  18552199
• Transcriptome analysis of proliferating Arabidopsis endosperm reveals biological implications for the control of syncytial division, cytokinin signaling, and gene expression regulation.   DOI:  10.1104/pp.108.128108 ;  PMID:  18923020
• Systematic localization of the Arabidopsis core cell cycle proteins reveals novel cell division complexes.   DOI:  10.1104/pp.109.148643 ;  PMID:  20018602
• Expression of Kip-related protein 4 gene (KRP4) in response to auxin and cytokinin during growth of Arabidopsis thaliana.   DOI:  10.5483/bmbrep.2010.43.4.273 ;  PMID:  20423613
• Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.   DOI:  10.1038/msb.2010.53 ;  PMID:  20706207
• Whole-mount confocal imaging of nuclei in giant feeding cells induced by root-knot nematodes in Arabidopsis.   DOI:  10.1111/j.1469-8137.2012.04175.x ;  PMID:  22616777
• Downregulation of multiple CDK inhibitor ICK/KRP genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis.   DOI:  10.1111/tpj.12228 ;  PMID:  23647236
• Arabidopsis JAGGED links floral organ patterning to tissue growth by repressing Kip-related cell cycle inhibitors.   DOI:  10.1073/pnas.1320457111 ;  PMID:  24497510
• Down-regulation of multiple CDK inhibitor ICK/KRP genes promotes cell proliferation, callus induction and plant regeneration in Arabidopsis.   DOI:  10.3389/fpls.2015.00825 ;  PMID:  26528298
• The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4.   DOI:  10.1093/jxb/erv576 ;  PMID:  26773810
• AtPRMT5 Regulates Shoot Regeneration through Mediating Histone H4R3 Dimethylation on KRPs and Pre-mRNA Splicing of RKP in Arabidopsis.   DOI:  10.1016/j.molp.2016.10.010 ;  PMID:  27780782
• Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.   DOI:  10.1111/pce.12912 ;  PMID:  28103637
• Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule.   DOI:  10.1371/journal.pgen.1007230 ;  PMID:  29513662
• Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.   DOI:  10.1111/nph.15458 ;  PMID:  30267580
• Cell size controlled in plants using DNA content as an internal scale.   DOI:  10.1126/science.abb4348 ;  PMID:  34112688
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519

Sequences: