Gene Details:

• Gene ID: AT2G31970
• Gene Symbol: ATRAD50, RAD50
• Gene Name:
• Description: DNA repair-recombination protein (RAD50);(source:Araport11)
• TAIR Accession: locus:2045437
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G31970.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)
• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)

Gene Ontology:

• GO:0070192  — involved in — chromosome organization involved in meiotic cell cycle
• GO:0006302  — acts upstream of or within — double-strand break repair
• GO:0007004  — involved in — telomere maintenance via telomerase
• GO:0032508  — involved in — DNA duplex unwinding
• GO:0005634  — located in — nucleus
• GO:0090305  — involved in — nucleic acid phosphodiester bond hydrolysis
• GO:0003691  — enables — double-stranded telomeric DNA binding
• GO:0051880  — enables — G-quadruplex DNA binding
• GO:0006302  — involved in — double-strand break repair
• GO:0006312  — acts upstream of or within — mitotic recombination
• GO:0000723  — acts upstream of or within — telomere maintenance
• GO:0016233  — acts upstream of or within — telomere capping
• GO:0030870  — part of — Mre11 complex
• GO:0043047  — enables — single-stranded telomeric DNA binding
• GO:0005737  — located in — cytoplasm
• GO:0005515  — enables — protein binding
• GO:0016887  — enables — ATP hydrolysis activity
• GO:0000722  — involved in — telomere maintenance via recombination
• GO:0000794  — is active in — condensed nuclear chromosome

Germplasm Phenotype:

• Atrad50  — High levels of double-strand breaks.
• Atrad50  — Hyperaccumulation of AtSPO11-1 in meiocytes.
• rad50  — Sterile, produces numerous flowers but small, empty siliques.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen ,  plant sperm cell ,  pollen

Literature:

• RAD50 function is essential for telomere maintenance in Arabidopsis.   DOI:  10.1073/pnas.98.4.1711 ;  PMID:  11172016
• Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity.   DOI:  10.1046/j.1365-313x.2001.00928.x ;  PMID:  11169180
• Homologous recombination in planta is stimulated in the absence of Rad50.   DOI:  10.1093/embo-reports/kve069 ;  PMID:  11306548
• The plant Rad50-Mre11 protein complex.   DOI:  10.1016/s0014-5793(02)02536-x ;  PMID:  11959125
• Meiotic defects in the Arabidopsis rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination.   DOI:  10.1007/s00412-004-0309-1 ;  PMID:  15309561
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Two roles for Rad50 in telomere maintenance.   DOI:  10.1038/sj.emboj.7601345 ;  PMID:  16990794
• PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus.   DOI:  10.1073/pnas.0906273106 ;  PMID:  19918061
• Distinct roles of the ATR kinase and the Mre11-Rad50-Nbs1 complex in the maintenance of chromosomal stability in Arabidopsis.   DOI:  10.1105/tpc.110.078527 ;  PMID:  20876831
• Systematic identification of functional plant modules through the integration of complementary data sources.   DOI:  10.1104/pp.112.196725 ;  PMID:  22589469
• Evidence for distinct functions of MRE11 in Arabidopsis meiosis.   DOI:  10.1371/journal.pone.0078760 ;  PMID:  24205310
• Phosphorylation of WHIRLY1 by CIPK14 Shifts Its Localization and Dual Functions in Arabidopsis.   DOI:  10.1016/j.molp.2017.03.011 ;  PMID:  28412544
• PHS1 regulates meiotic recombination and homologous chromosome pairing by controlling the transport of RAD50 to the nucleus.   DOI:  10.1073/pnas.0906273106 ;  PMID:  19918061

Sequences: