Gene Details:

• Gene ID: AT2G30390
• Gene Symbol: ATFC-II, FC-II, FC2
• Gene Name: ferrochelatase 2
• Description: ferrochelatase 2;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G30390.1     AT2G30390.2

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Germplasm Phenotype:

• fc2-1  — fc2-1 seedlings do not become green when grown in short days (4 or 8 hours light).They are defective in de-etiolation response in short days. This is likely due to accumulation of protoporphyrin IX which in turn causes production of reactive oxygen species and triggers chloroplast degradation pathway.
• fc2-1/pub4-6  — Seedlings green normally when exposed to 4 hour light cycle. Plants still produce ROS and chloroplasts look abnormal but do not degrade.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen

Literature:

• Two different genes encode ferrochelatase in Arabidopsis: mapping, expression and subcellular targeting of the precursor proteins.   DOI:  10.1046/j.1365-313x.1998.00235.x ;  PMID:  9753778
• Arabidopsis thaliana ferrochelatase-I and -II are not imported into Arabidopsis mitochondria.   DOI:  10.1016/s0014-5793(01)02925-8 ;  PMID:  11602264
• Expression analysis of the two ferrochelatase genes in Arabidopsis in different tissues and under stress conditions reveals their different roles in haem biosynthesis.   DOI:  10.1023/a:1019959224271 ;  PMID:  12374307
• Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.   DOI:  10.1023/a:1023005504702 ;  PMID:  12777052
• Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.   DOI:  10.1074/jbc.M308435200 ;  PMID:  14576160
• Functional analysis of each blue light receptor, cry1, cry2, phot1, and phot2, by using combinatorial multiple mutants in Arabidopsis.   DOI:  10.1073/pnas.0305984101 ;  PMID:  14982991
• Gene expression profiling of the tetrapyrrole metabolic pathway in Arabidopsis with a mini-array system.   DOI:  10.1104/pp.104.042408 ;  PMID:  15326282
• An extensive (co-)expression analysis tool for the cytochrome P450 superfamily in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-8-47 ;  PMID:  18433503
• PIF1 directly and indirectly regulates chlorophyll biosynthesis to optimize the greening process in Arabidopsis.   DOI:  10.1073/pnas.0803611105 ;  PMID:  18591656
• Light signalling pathways regulating the Mg-chelatase branchpoint of chlorophyll synthesis during de-etiolation in Arabidopsis thaliana.   DOI:  10.1039/b802596g ;  PMID:  18846290
• Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants.   DOI:  10.1016/j.cub.2011.04.004 ;  PMID:  21565502
• Functional characterization of the two ferrochelatases in Arabidopsis thaliana.   DOI:  10.1111/pce.12248 ;  PMID:  24329537
• Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts.   DOI:  10.1126/science.aac7444 ;  PMID:  26494759
• Allocation of Heme Is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells.   DOI:  10.3389/fpls.2016.01326 ;  PMID:  27630653
• Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana.   DOI:  10.3389/fpls.2016.01811 ;  PMID:  27990150
• Complementation studies of the Arabidopsis fc1 mutant substantiate essential functions of ferrochelatase 1 during embryogenesis and salt stress.   DOI:  10.1111/pce.13448 ;  PMID:  30242849
• Roles for the chloroplast-localized pentatricopeptide repeat protein 30 and the 'mitochondrial' transcription termination factor 9 in chloroplast quality control.   DOI:  10.1111/tpj.14963 ;  PMID:  32779277
• The core autophagy machinery is not required for chloroplast singlet oxygen-mediated cell death in the Arabidopsis thaliana plastid ferrochelatase two mutant.   DOI:  10.1186/s12870-021-03119-x ;  PMID:  34281507
• Singlet Oxygen Leads to Structural Changes to Chloroplasts during their Degradation in the Arabidopsis thaliana plastid ferrochelatase two Mutant.   DOI:  10.1093/pcp/pcab167 ;  PMID:  34850209
• Multiple pathways mediate chloroplast singlet oxygen stress signaling.   DOI:  10.1007/s11103-022-01319-z ;  PMID:  36266500
• FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.   DOI:  10.1111/nph.18952 ;  PMID:  37161708
• Arabidopsis thaliana ferrochelatase-I and -II are not imported into Arabidopsis mitochondria.   DOI:  10.1016/s0014-5793(01)02925-8 ;  PMID:  11602264
• The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions.   DOI:  10.1016/j.cub.2004.02.039 ;  PMID:  15028209
• Sorting signals, N-terminal modifications and abundance of the chloroplast proteome.   DOI:  10.1371/journal.pone.0001994 ;  PMID:  18431481

Sequences: