Gene Details:

• Gene ID: AT2G28160
• Gene Symbol: ATBHLH029, ATBHLH29, ATFIT1, BHLH029, FIT, FIT1, FRU
• Gene Name: BASIC HELIX-LOOP-HELIX PROTEIN 29, BASIC HELIX-LOOP-HELIX PROTEIN 29, ARABIDOPSIS FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1, BASIC HELIX-LOOP-HELIX PROTEIN 29, FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR, FE-DEFICIENCY INDUCED TRANSCRIPTION FACTOR 1, FER-like regulator of iron uptake
• Description: FER-like regulator of iron uptake;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G28160.1     AT2G28160.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Function-related keywords:

• root

Literature:

• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• Expression profiling of cytokinin action in Arabidopsis.   DOI:  10.1104/pp.103.021436 ;  PMID:  12913156
• The Arabidopsis basic/helix-loop-helix transcription factor family.   DOI:  10.1105/tpc.013839 ;  PMID:  12897250
• Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.   DOI:  10.1105/tpc.151140 ;  PMID:  14600211
• The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response.   DOI:  10.1105/tpc.104.024315 ;  PMID:  15539473
• Analysis of sequence, map position, and gene expression reveals conserved essential genes for iron uptake in Arabidopsis and tomato.   DOI:  10.1104/pp.104.047233 ;  PMID:  15531708
• AtbHLH29 of Arabidopsis thaliana is a functional ortholog of tomato FER involved in controlling iron acquisition in strategy I plants.   DOI:  10.1038/sj.cr.7290331 ;  PMID:  16117851
• 12-oxo-phytodienoic acid triggers expression of a distinct set of genes and plays a role in wound-induced gene expression in Arabidopsis.   DOI:  10.1104/pp.105.067058 ;  PMID:  16258017
• FRU (BHLH029) is required for induction of iron mobilization genes in Arabidopsis thaliana.   DOI:  10.1016/j.febslet.2004.10.062 ;  PMID:  15556641
• Genome-wide expression profiling of ARABIDOPSIS RESPONSE REGULATOR 7(ARR7) overexpression in cytokinin response.   DOI:  10.1007/s00438-006-0177-x ;  PMID:  17061125
• FIT, the FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR in Arabidopsis.   DOI:  10.1016/j.plaphy.2007.03.006 ;  PMID:  17466530
• Iron deficiency-mediated stress regulation of four subgroup Ib BHLH genes in Arabidopsis thaliana.   DOI:  10.1007/s00425-007-0535-x ;  PMID:  17516080
• Cytokinins negatively regulate the root iron uptake machinery in Arabidopsis through a growth-dependent pathway.   DOI:  10.1111/j.1365-313X.2008.03502.x ;  PMID:  18397377
• A soil bacterium regulates plant acquisition of iron via deficiency-inducible mechanisms.   DOI:  10.1111/j.1365-313X.2009.03803.x ;  PMID:  19154225
• FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis.   DOI:  10.1038/cr.2008.26 ;  PMID:  18268542
• Carbon monoxide improves adaptation of Arabidopsis to iron deficiency.   DOI:  10.1111/j.1467-7652.2009.00469.x ;  PMID:  20055961
• Ethylene and nitric oxide involvement in the up-regulation of key genes related to iron acquisition and homeostasis in Arabidopsis.   DOI:  10.1093/jxb/erq203 ;  PMID:  20627899
• Interaction between the bHLH transcription factor FIT and ETHYLENE INSENSITIVE3/ETHYLENE INSENSITIVE3-LIKE1 reveals molecular linkage between the regulation of iron acquisition and ethylene signaling in Arabidopsis.   DOI:  10.1105/tpc.111.084715 ;  PMID:  21586684
• Fitting into the harsh reality: regulation of iron-deficiency responses in dicotyledonous plants.   DOI:  10.1093/mp/ssr065 ;  PMID:  21873619
• Suppression of Fe deficiency gene expression by jasmonate.   DOI:  10.1016/j.plaphy.2011.01.025 ;  PMID:  21334215
• Posttranslational regulation of the iron deficiency basic helix-loop-helix transcription factor FIT is affected by iron and nitric oxide.   DOI:  10.1104/pp.111.183285 ;  PMID:  21972265
• Reciprocal interaction of the circadian clock with the iron homeostasis network in Arabidopsis.   DOI:  10.1104/pp.112.208603 ;  PMID:  23250624
• Looking for the hub in Fe signaling.   DOI:  10.4161/psb.20150 ;  PMID:  22580691
• Feruloyl-CoA 6'-Hydroxylase1-dependent coumarins mediate iron acquisition from alkaline substrates in Arabidopsis.   DOI:  10.1104/pp.113.228544 ;  PMID:  24246380
• Uranium perturbs signaling and iron uptake response in Arabidopsis thaliana roots.   DOI:  10.1039/c4mt00005f ;  PMID:  24549117
• Iron and FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR-dependent regulation of proteins and genes in Arabidopsis thaliana roots.   DOI:  10.1002/pmic.201400351 ;  PMID:  25951126
• Carbon Monoxide Interacts with Auxin and Nitric Oxide to Cope with Iron Deficiency in Arabidopsis.   DOI:  10.3389/fpls.2016.00112 ;  PMID:  27014280
• Paenibacillus polymyxa BFKC01 enhances plant iron absorption via improved root systems and activated iron acquisition mechanisms.   DOI:  10.1016/j.plaphy.2016.04.025 ;  PMID:  27105423
• Exogenous Melatonin Improves Plant Iron Deficiency Tolerance via Increased Accumulation of Polyamine-Mediated Nitric Oxide.   DOI:  10.3390/ijms17111777 ;  PMID:  27792144
• The G-Box Transcriptional Regulatory Code in Arabidopsis.   DOI:  10.1104/pp.17.01086 ;  PMID:  28864470
• S-Nitrosoglutathione works downstream of nitric oxide to mediate iron-deficiency signaling in Arabidopsis.   DOI:  10.1111/tpj.13850 ;  PMID:  29396986
• Four IVa bHLH Transcription Factors Are Novel Interactors of FIT and Mediate JA Inhibition of Iron Uptake in Arabidopsis.   DOI:  10.1016/j.molp.2018.06.005 ;  PMID:  29960107
• The Putative Peptide Gene FEP1 Regulates Iron Deficiency Response in Arabidopsis.   DOI:  10.1093/pcp/pcy145 ;  PMID:  30032190
• The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana.   DOI:  10.1007/s10265-018-1068-z ;  PMID:  30417276
• New aspects of iron-copper crosstalk uncovered by transcriptomic characterization of Col-0 and the copper uptake mutant spl7 in Arabidopsis thaliana.   DOI:  10.1039/c8mt00287h ;  PMID:  30460953
• CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.   DOI:  10.1016/j.devcel.2019.01.006 ;  PMID:  30713077
• Small-Molecules Selectively Modulate Iron-Deficiency Signaling Networks in Arabidopsis.   DOI:  10.3389/fpls.2019.00008 ;  PMID:  30766541
• Iron and Phosphate Deficiency Regulators Concertedly Control Coumarin Profiles in Arabidopsis thaliana Roots During Iron, Phosphate, and Combined Deficiencies.   DOI:  10.3389/fpls.2019.00113 ;  PMID:  30804973
• PRC2-Mediated H3K27me3 Contributes to Transcriptional Regulation of FIT-Dependent Iron Deficiency Response.   DOI:  10.3389/fpls.2019.00627 ;  PMID:  31156682
• FIT-Binding Proteins and Their Functions in the Regulation of Fe Homeostasis.   DOI:  10.3389/fpls.2019.00844 ;  PMID:  31297128
• Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling.   DOI:  10.1073/pnas.1907971116 ;  PMID:  31413196
• Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR.   DOI:  10.1111/nph.16168 ;  PMID:  31487399
• The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.   DOI:  10.1073/pnas.1916892116 ;  PMID:  31776249
• The Transcription Factor bHLH121 Interacts with bHLH105 (ILR3) and Its Closest Homologs to Regulate Iron Homeostasis in Arabidopsis.   DOI:  10.1105/tpc.19.00541 ;  PMID:  31776233
• Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT.   DOI:  10.1002/pld3.190 ;  PMID:  31879716
• Putative cis-Regulatory Elements Predict Iron Deficiency Responses in Arabidopsis Roots.   DOI:  10.1104/pp.19.00760 ;  PMID:  31937681
• bHLH121 Functions as a Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.   DOI:  10.1016/j.molp.2020.01.006 ;  PMID:  31962167
• Alteration of iron responsive gene expression in Arabidopsis glutaredoxin S17 loss of function plants with or without iron stress.   DOI:  10.1080/15592324.2020.1758455 ;  PMID:  32351167
• Deregulated High Affinity Copper Transport Alters Iron Homeostasis in Arabidopsis.   DOI:  10.3389/fpls.2020.01106 ;  PMID:  32793263
• The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis.   DOI:  10.1016/j.gene.2020.145372 ;  PMID:  33346096
• All together now: regulation of the iron deficiency response.   DOI:  10.1093/jxb/erab003 ;  PMID:  33449088
• FIT and bHLH Ib transcription factors modulate iron and copper crosstalk in Arabidopsis.   DOI:  10.1111/pce.14000 ;  PMID:  33464620
• Comparative Study of Several Fe Deficiency Responses in the Arabidopsis thaliana Ethylene Insensitive Mutants ein2-1 and ein2-5.   DOI:  10.3390/plants10020262 ;  PMID:  33573082
• PAP/SAL1 retrograde signaling pathway modulates iron deficiency response in alkaline soils.   DOI:  10.1016/j.plantsci.2020.110808 ;  PMID:  33568304
• Interconnection of iron and osmotic stress signalling in plants: is FIT a regulatory hub to cross-connect abscisic acid responses?   DOI:  10.1111/plb.13261 ;  PMID:  33772999
• Physiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency.   DOI:  10.1038/s41598-021-94908-9 ;  PMID:  34330973
• bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors.   DOI:  10.1093/plphys/kiab540 ;  PMID:  34894263
• Loss-of-function mutations in the ERF96 gene enhance iron-deficient tolerance in Arabidopsis.   DOI:  10.1016/j.plaphy.2022.02.002 ;  PMID:  35158317
• MNB1 gene is involved in regulating the iron-deficiency stress response in Arabidopsis thaliana.   DOI:  10.1186/s12870-022-03553-5 ;  PMID:  35346040
• Crosstalk Between Iron and Sulfur Homeostasis Networks in Arabidopsis.   DOI:  10.3389/fpls.2022.878418 ;  PMID:  35755678
• ZAT10 plays dual roles in cadmium uptake and detoxification in Arabidopsis.   DOI:  10.3389/fpls.2022.994100 ;  PMID:  36110357
• Fe deficiency-induced ethylene synthesis confers resistance to Botrytis cinerea.   DOI:  10.1111/nph.18638 ;  PMID:  36440498
• The transcription factor MYC1 interacts with FIT to negatively regulate iron homeostasis in Arabidopsis thaliana.   DOI:  10.1111/tpj.16130 ;  PMID:  36721966
• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• Analysis of sequence, map position, and gene expression reveals conserved essential genes for iron uptake in Arabidopsis and tomato.   DOI:  10.1104/pp.104.047233 ;  PMID:  15531708
• The tomato fer gene encoding a bHLH protein controls iron-uptake responses in roots.   DOI:  10.1073/pnas.212448699 ;  PMID:  12370409
• AtIREG2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in Arabidopsis thaliana roots.   DOI:  10.1074/jbc.M601062200 ;  PMID:  16790430
• FIT, the FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR in Arabidopsis.   DOI:  10.1016/j.plaphy.2007.03.006 ;  PMID:  17466530
• Cytokinins negatively regulate the root iron uptake machinery in Arabidopsis through a growth-dependent pathway.   DOI:  10.1111/j.1365-313X.2008.03502.x ;  PMID:  18397377

Sequences: