Gene Details:

• Gene ID: AT2G27250
• Gene Symbol: AtCLV3, CLV3
• Gene Name: CLAVATA3
• Description: CLAVATA3;(source:Araport11)
• TAIR Accession: locus:2005502
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G27250.1     AT2G27250.2     AT2G27250.3

Plant Ontology Annotations:

• PO:0000229  — flower meristem — floral meristem (exact), mersitema floral (Spanish, exact), 花芽分裂組織 (Japanese, exact), floral apical meristem (related), Poaceae floret meristem (narrow), ear floret meristem (narrow), floret meristem (narrow), tassel floret meristem (narrow)
• PO:0020144  — apical meristem — AM (exact), meristema apical (Spanish, exact), 頂端分裂組織 (Japanese, exact), primary meristem (related), promeristem (broad)
• PO:0000224  — central zone — zona central (Spanish, exact), 中央帯 (Japanese, exact), central initiation zone (related)

Gene Ontology:

• GO:0033612  — enables — receptor serine/threonine kinase binding
• GO:0045168  — involved in — cell-cell signaling involved in cell fate commitment
• GO:0005576  — located in — extracellular region
• GO:0005515  — enables — protein binding
• GO:0005739  — located in — mitochondrion
• GO:0048507  — acts upstream of or within — meristem development
• GO:0009934  — acts upstream of or within — regulation of meristem structural organization
• GO:0010074  — acts upstream of or within — maintenance of meristem identity
• GO:0045087  — acts upstream of or within — innate immune response
• GO:0045168  — acts upstream of or within — cell-cell signaling involved in cell fate commitment
• GO:0030154  — acts upstream of or within — cell differentiation
• GO:0016043  — acts upstream of or within — cellular component organization
• GO:0005102  — enables — signaling receptor binding
• GO:0007165  — acts upstream of or within — signal transduction
• GO:0048046  — located in — apoplast

Function-related keywords:

• flower meristem ,  apical meristem ,  central zone

Literature:

• Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity.   DOI:  10.1126/science.289.5479.617 ;  PMID:  10915624
• CLAVATA3, a multimeric ligand for the CLAVATA1 receptor-kinase.   DOI:  10.1126/science.289.5479.613 ;  PMID:  10915623
• Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana.   DOI:  10.1073/pnas.060034297 ;  PMID:  10781109
• The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the CLAVATA and WUSCHEL genes.   DOI:  10.1016/s0092-8674(00)80700-x ;  PMID:  10761929
• POLTERGEIST functions to regulate meristem development downstream of the CLAVATA loci.   DOI:  10.1242/dev.127.8.1661 ;  PMID:  10725242
• Signaling of cell fate decisions by CLAVATA3 in Arabidopsis shoot meristems.   DOI:  10.1126/science.283.5409.1911 ;  PMID:  10082464
• The CLAVATA1 receptor-like kinase requires CLAVATA3 for its assembly into a signaling complex that includes KAPP and a Rho-related protein.   DOI:  10.1105/tpc.11.3.393 ;  PMID:  10072399
• CLAVATA2, a regulator of meristem and organ development in Arabidopsis.   DOI:  10.1242/dev.125.19.3843 ;  PMID:  9729492
• Cellular parameters of the shoot apical meristem in Arabidopsis.   DOI:  10.1105/tpc.10.8.1375 ;  PMID:  9707536
• The WIGGUM gene is required for proper regulation of floral meristem size in Arabidopsis.   DOI:  10.1242/dev.125.14.2545 ;  PMID:  9636070
• A genetic screen for modifiers of UFO meristem activity identifies three novel FUSED FLORAL ORGANS genes required for early flower development in Arabidopsis.   DOI:  10.1093/genetics/149.2.579 ;  PMID:  9611175
• MGOUN1 and MGOUN2: two genes required for primordium initiation at the shoot apical and floral meristems in Arabidopsis thaliana.   DOI:  10.1242/dev.125.7.1253 ;  PMID:  9477323
• FON1, an Arabidopsis gene that terminates floral meristem activity and controls flower organ number.   DOI:  10.1105/tpc.9.2.115 ;  PMID:  9061945
• Genetic control of shoot and flower meristem behavior.   DOI:  10.1016/s0955-0674(96)80089-5 ;  PMID:  8939670
• The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis.   DOI:  10.1242/dev.122.5.1567 ;  PMID:  8625843
• Correlative controls of senescence and plant death in Arabidopsis thaliana (Brassicaceae).   DOI:  10.1093/jexbot/52.364.2151 ;  PMID:  11604454
• SHEPHERD is the Arabidopsis GRP94 responsible for the formation of functional CLAVATA proteins.   DOI:  10.1093/emboj/21.5.898 ;  PMID:  11867518
• Regulation of CLV3 expression by two homeobox genes in Arabidopsis.   DOI:  10.1104/pp.001867 ;  PMID:  12068101
• CLV3 is localized to the extracellular space, where it activates the Arabidopsis CLAVATA stem cell signaling pathway.   DOI:  10.1105/tpc.002196 ;  PMID:  12034890
• A large family of genes that share homology with CLAVATA3.   DOI:  10.1104/pp.126.3.939 ;  PMID:  11457943
• HAR1 mediates systemic regulation of symbiotic organ development.   DOI:  10.1038/nature01231 ;  PMID:  12442172
• The Arabidopsis CLV3-like (CLE) genes are expressed in diverse tissues and encode secreted proteins.   DOI:  10.1023/a:1022038932376 ;  PMID:  12602871
• The DORNROSCHEN/ENHANCER OF SHOOT REGENERATION1 gene of Arabidopsis acts in the control of meristem ccll fate and lateral organ development.   DOI:  10.1105/tpc.009480 ;  PMID:  12615942
• Loss of CLE40, a protein functionally equivalent to the stem cell restricting signal CLV3, enhances root waving in Arabidopsis.   DOI:  10.1007/s00427-003-0329-5 ;  PMID:  12743822
• Stem cell homeostasis in the Arabidopsis shoot meristem is regulated by intercellular movement of CLAVATA3 and its sequestration by CLAVATA1.   DOI:  10.1242/dev.00525 ;  PMID:  12783788
• Leucine-rich repeat receptor kinases in plants: structure, function, and signal transduction pathways.   DOI:  10.1016/S0074-7696(04)34001-5 ;  PMID:  15066372
• HANABA TARANU is a GATA transcription factor that regulates shoot apical meristem and flower development in Arabidopsis.   DOI:  10.1105/tpc.104.024869 ;  PMID:  15367721
• Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases.   DOI:  10.1073/pnas.0402385101 ;  PMID:  15128936
• Photoperiod regulates flower meristem development in Arabidopsis thaliana.   DOI:  10.1534/genetics.104.033357 ;  PMID:  15489527
• CORONA, a member of the class III homeodomain leucine zipper gene family in Arabidopsis, regulates stem cell specification and organogenesis.   DOI:  10.1105/tpc.104.026179 ;  PMID:  15705957
• Peptide signals and their receptors in higher plants.   DOI:  10.1016/s1360-1385(01)02148-3 ;  PMID:  11738382
• Modeling the organization of the WUSCHEL expression domain in the shoot apical meristem.   DOI:  10.1093/bioinformatics/bti1036 ;  PMID:  15961462
• The 14-amino acid CLV3, CLE19, and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway.   DOI:  10.1105/tpc.105.034009 ;  PMID:  16055633
• Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex.   DOI:  10.1126/science.1116261 ;  PMID:  16210497
• A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.   DOI:  10.1007/s00299-005-0075-4 ;  PMID:  16408177
• Evidence for functional conservation, sufficiency, and proteolytic processing of the CLAVATA3 CLE domain.   DOI:  10.1104/pp.105.072678 ;  PMID:  16407446
• APETALA2 regulates the stem cell niche in the Arabidopsis shoot meristem.   DOI:  10.1105/tpc.105.038398 ;  PMID:  16387832
• Gain-of-function phenotypes of many CLAVATA3/ESR genes, including four new family members, correlate with tandem variations in the conserved CLAVATA3/ESR domain.   DOI:  10.1104/pp.105.075515 ;  PMID:  16489133
• Dynamic and compensatory responses of Arabidopsis shoot and floral meristems to CLV3 signaling.   DOI:  10.1105/tpc.105.040444 ;  PMID:  16603652
• The CLAVATA3/ESR motif of CLAVATA3 is functionally independent from the nonconserved flanking sequences.   DOI:  10.1104/pp.106.080671 ;  PMID:  16751438
• A plant peptide encoded by CLV3 identified by in situ MALDI-TOF MS analysis.   DOI:  10.1126/science.1128439 ;  PMID:  16902141
• Dodeca-CLE peptides as suppressors of plant stem cell differentiation.   DOI:  10.1126/science.1128436 ;  PMID:  16902140
• Ligand mimicry? Plant-parasitic nematode polypeptide with similarity to CLAVATA3.   DOI:  10.1016/S1360-1385(03)00003-7 ;  PMID:  12597870
• Conservation and diversification of meristem maintenance mechanism in Oryza sativa: Function of the FLORAL ORGAN NUMBER2 gene.   DOI:  10.1093/pcp/pcl025 ;  PMID:  17056620
• Developmental characterization of the fasciated locus and mapping of Arabidopsis candidate genes involved in the control of floral meristem size and carpel number in tomato.   DOI:  10.1139/g06-059 ;  PMID:  17036074
• The floral organ number4 gene encoding a putative ortholog of Arabidopsis CLAVATA3 regulates apical meristem size in rice.   DOI:  10.1104/pp.106.086736 ;  PMID:  17012407
• CLE peptide ligands and their roles in establishing meristems.   DOI:  10.1016/j.pbi.2006.11.003 ;  PMID:  17129751
• CLV3/ESR-related (CLE) peptides as intercellular signaling molecules in plants.   DOI:  10.1002/tcr.20091 ;  PMID:  17304552
• Mutations in the TORNADO2 gene affect cellular decisions in the peripheral zone of the shoot apical meristem of Arabidopsis thaliana.   DOI:  10.1007/s11103-006-9105-z ;  PMID:  17351828
• Divergent functions of VTI12 and VTI11 in trafficking to storage and lytic vacuoles in Arabidopsis.   DOI:  10.1073/pnas.0611147104 ;  PMID:  17360696
• SHA1, a novel RING finger protein, functions in shoot apical meristem maintenance in Arabidopsis.   DOI:  10.1111/j.1365-313X.2007.03062.x ;  PMID:  17461786
• Pattern formation during de novo assembly of the Arabidopsis shoot meristem.   DOI:  10.1242/dev.010298 ;  PMID:  17827180
• The CLE family of plant polypeptide signaling molecules.   DOI:  10.1007/s00018-007-7411-5 ;  PMID:  18034320
• Gain-of-function phenotypes of chemically synthetic CLAVATA3/ESR-related (CLE) peptides in Arabidopsis thaliana and Oryza sativa.   DOI:  10.1093/pcp/pcm154 ;  PMID:  17991631
• Arabidopsis CLV3 peptide directly binds CLV1 ectodomain.   DOI:  10.1126/science.1150083 ;  PMID:  18202283
• The receptor kinase CORYNE of Arabidopsis transmits the stem cell-limiting signal CLAVATA3 independently of CLAVATA1.   DOI:  10.1105/tpc.107.057547 ;  PMID:  18381924
• Signals derived from YABBY gene activities in organ primordia regulate growth and partitioning of Arabidopsis shoot apical meristems.   DOI:  10.1105/tpc.107.057877 ;  PMID:  18469164
• The EPIP peptide of INFLORESCENCE DEFICIENT IN ABSCISSION is sufficient to induce abscission in arabidopsis through the receptor-like kinases HAESA and HAESA-LIKE2.   DOI:  10.1105/tpc.108.059139 ;  PMID:  18660431
• Vascular signalling mediated by ZWILLE potentiates WUSCHEL function during shoot meristem stem cell development in the Arabidopsis embryo.   DOI:  10.1242/dev.023648 ;  PMID:  18653559
• Functional diversification of CLAVATA3-related CLE proteins in meristem maintenance in rice.   DOI:  10.1105/tpc.107.057257 ;  PMID:  18676878
• BAM receptors regulate stem cell specification and organ development through complex interactions with CLAVATA signaling.   DOI:  10.1534/genetics.108.091108 ;  PMID:  18780746
• A quantitative and dynamic model for plant stem cell regulation.   DOI:  10.1371/journal.pone.0003553 ;  PMID:  18958283
• The receptor-like kinase SOL2 mediates CLE signaling in Arabidopsis.   DOI:  10.1093/pcp/pcn148 ;  PMID:  18854335
• Dual assay for MCLV3 activity reveals structure-activity relationship of CLE peptides.   DOI:  10.1016/j.bbrc.2008.09.139 ;  PMID:  18848920
• Plant CLE peptides from two distinct functional classes synergistically induce division of vascular cells.   DOI:  10.1073/pnas.0809395105 ;  PMID:  19011104
• MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis.   DOI:  10.1111/j.1365-313X.2008.03738.x ;  PMID:  19000164
• Pluripotency of Arabidopsis xylem pericycle underlies shoot regeneration from root and hypocotyl explants grown in vitro.   DOI:  10.1111/j.1365-313X.2008.03715.x ;  PMID:  18980654
• Influence of clavata3-2 mutation on early flower development in Arabidopsis thaliana: quantitative analysis of changing geometry.   DOI:  10.1093/jxb/ern312 ;  PMID:  19088334
• WUSCHEL regulates cell differentiation during anther development.   DOI:  10.1016/j.ydbio.2006.09.013 ;  PMID:  17027956
• Multiple MONOPTEROS-dependent pathways are involved in leaf initiation.   DOI:  10.1104/pp.108.119396 ;  PMID:  18685044
• A signaling module controlling the stem cell niche in Arabidopsis root meristems.   DOI:  10.1016/j.cub.2009.03.060 ;  PMID:  19398337
• Enhanced AGAMOUS expression in the centre of the Arabidopsis flower causes ectopic expression over its outer expression boundaries.   DOI:  10.1007/s00425-009-0966-7 ;  PMID:  19554348
• A glycopeptide regulating stem cell fate in Arabidopsis thaliana.   DOI:  10.1038/nchembio.182 ;  PMID:  19525968
• The association of homeobox gene expression with stem cell formation and morphogenesis in cultured Medicago truncatula.   DOI:  10.1007/s00425-009-0988-1 ;  PMID:  19639337
• Overexpression of an Arabidopsis gene encoding a subtilase (AtSBT5.4) produces a clavata-like phenotype.   DOI:  10.1007/s00425-009-0976-5 ;  PMID:  19588163
• Structural and functional diversity of CLAVATA3/ESR (CLE)-like genes from the potato cyst nematode Globodera rostochiensis.   DOI:  10.1094/MPMI-22-9-1128 ;  PMID:  19656047
• The Shoot Apical Meristem Size Regulated by FON4 in Rice.   DOI:  10.4161/psb.2.2.3641 ;  PMID:  19704753
• Analysis of interactions among the CLAVATA3 receptors reveals a direct interaction between CLAVATA2 and CORYNE in Arabidopsis.   DOI:  10.1111/j.1365-313X.2009.04049.x ;  PMID:  19843317
• FON2 SPARE1 redundantly regulates floral meristem maintenance with FLORAL ORGAN NUMBER2 in rice.   DOI:  10.1371/journal.pgen.1000693 ;  PMID:  19834537
• Developmental consequences of the tumorous shoot development1 mutation, a novel allele of the cellulose-synthesizing KORRIGAN1 gene.   DOI:  10.1007/s11103-009-9546-2 ;  PMID:  19826767
• Is the Arabidopsis root niche protected by sequestration of the CLE40 signal by its putative receptor ACR4?   DOI:  10.4161/psb.4.7.8970 ;  PMID:  19820344
• Evolution of CLE signaling: origins of the CLV1 and SOL2/CRN receptor diversity.   DOI:  10.4161/psb.4.6.8391 ;  PMID:  19816140
• Stem cell signaling in Arabidopsis requires CRN to localize CLV2 to the plasma membrane.   DOI:  10.1104/pp.109.149930 ;  PMID:  19933383
• Role of A-type ARABIDOPSIS RESPONSE REGULATORS in meristem maintenance and regeneration.   DOI:  10.1016/j.ejcb.2009.11.016 ;  PMID:  20018401
• CLE peptide signaling during plant development.   DOI:  10.1007/s00709-009-0095-y ;  PMID:  20016993
• Multiple receptor complexes assembled for transmitting CLV3 signaling in Arabidopsis.   DOI:  10.4161/psb.5.3.10790 ;  PMID:  20220313
• Identification of novel markers for stem-cell niche of Arabidopsis shoot apex.   DOI:  10.1016/j.gep.2010.05.004 ;  PMID:  20580859
• Arabinosylated glycopeptide hormones: new insights into CLAVATA3 structure.   DOI:  10.1016/j.pbi.2010.05.008 ;  PMID:  20580598
• Cytokinin and auxin regulates WUS induction and inflorescence regeneration in vitro in Arabidopsis.   DOI:  10.1007/s00299-010-0879-8 ;  PMID:  20514542
• A parasitism gene from a plant-parasitic nematode with function similar to CLAVATA3/ESR (CLE) of Arabidopsis thaliana.   DOI:  10.1111/j.1364-3703.2005.00270.x ;  PMID:  20565649
• CLAVATA2 forms a distinct CLE-binding receptor complex regulating Arabidopsis stem cell specification.   DOI:  10.1111/j.1365-313X.2010.04295.x ;  PMID:  20626648
• CLE peptides can negatively regulate protoxylem vessel formation via cytokinin signaling.   DOI:  10.1093/pcp/pcq129 ;  PMID:  20802224
• Convergence of the 26S proteasome and the REVOLUTA pathways in regulating inflorescence and floral meristem functions in Arabidopsis.   DOI:  10.1093/jxb/erq277 ;  PMID:  20797995
• The cysteine pairs in CLV2 are not necessary for sensing the CLV3 peptide in shoot and root meristems.   DOI:  10.1111/j.1744-7909.2010.00978.x ;  PMID:  20738721
• CLE14/CLE20 peptides may interact with CLAVATA2/CORYNE receptor-like kinases to irreversibly inhibit cell division in the root meristem of Arabidopsis.   DOI:  10.1007/s00425-010-1236-4 ;  PMID:  20697738
• RPK2 is an essential receptor-like kinase that transmits the CLV3 signal in Arabidopsis.   DOI:  10.1242/dev.048199 ;  PMID:  20978082
• Mitogen-activated protein kinase regulated by the CLAVATA receptors contributes to shoot apical meristem homeostasis.   DOI:  10.1093/pcp/pcq157 ;  PMID:  20965998
• Analogs of the CLV3 peptide: synthesis and structure-activity relationships focused on proline residues.   DOI:  10.1093/pcp/pcq146 ;  PMID:  20926417
• Membrane distributions of two ligand-binding receptor complexes in the CLAVATA pathway.   DOI:  10.1111/j.1365-313X.2010.04295 ;  PMID:  21051944
• The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-10-285 ;  PMID:  21176196
• Identification of target ligands of CORYNE in Arabidopsis by phage display library.   DOI:  10.1111/j.1744-7909.2010.01028.x ;  PMID:  21214859
• CLE genes may act in a variety of tissues/cells and involve other signaling cascades in addition to CLV3-WUS-like pathways.   DOI:  10.4161/psb.6.1.14186 ;  PMID:  21270538
• Nematode CLE signaling in Arabidopsis requires CLAVATA2 and CORYNE.   DOI:  10.1111/j.1365-313X.2010.04433.x ;  PMID:  21265896
• CLE polypeptide signaling gene expression in Arabidopsis embryos.   DOI:  10.4161/psb.6.3.14553 ;  PMID:  21278487
• Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase.   DOI:  10.1016/j.cub.2011.01.039 ;  PMID:  21333538
• Stem-cell-triggered immunity through CLV3p-FLS2 signalling.   DOI:  10.1038/nature09958 ;  PMID:  21499263
• DNA uptake by Arabidopsis induces changes in the expression of CLE peptides which control root morphology.   DOI:  10.4161/psb.5.9.12477 ;  PMID:  21490419
• Over-expression of WOX1 leads to defects in meristem development and polyamine homeostasis in Arabidopsis.   DOI:  10.1111/j.1744-7909.2011.01054.x ;  PMID:  21658178
• Expression and functional analysis of a CLV3-like gene in the model legume Lotus japonicus.   DOI:  10.1093/pcp/pcr071 ;  PMID:  21652543
• Nucleostemin-like 1 is required for embryogenesis and leaf development in Arabidopsis.   DOI:  10.1007/s11103-011-9840-7 ;  PMID:  22058024
• Glycosides of hydroxyproline: some recent, unusual discoveries.   DOI:  10.1093/glycob/cwr188 ;  PMID:  22190471
• WUSCHEL protein movement mediates stem cell homeostasis in the Arabidopsis shoot apex.   DOI:  10.1101/gad.17258511 ;  PMID:  21979915
• Contributions of individual amino acid residues to the endogenous CLV3 function in shoot apical meristem maintenance in Arabidopsis.   DOI:  10.1093/mp/ssr120 ;  PMID:  22259020
• HAM proteins promote organ indeterminacy: but how?   DOI:  10.4161/psb.18958 ;  PMID:  22353859
• Proper regeneration from in vitro cultured Arabidopsis thaliana requires the microRNA-directed action of an auxin response factor.   DOI:  10.1111/j.1365-313X.2012.04944.x ;  PMID:  22335436
• Synergistic interaction of CLAVATA1, CLAVATA2, and RECEPTOR-LIKE PROTEIN KINASE 2 in cyst nematode parasitism of Arabidopsis.   DOI:  10.1094/MPMI-05-12-0118-FI ;  PMID:  22835273
• The shoot apical meristem regulatory peptide CLV3 does not activate innate immunity.   DOI:  10.1105/tpc.111.091264 ;  PMID:  22923673
• ERECTA-family receptor kinases regulate stem cell homeostasis via buffering its cytokinin responsiveness in the shoot apical meristem.   DOI:  10.1093/pcp/pcs109 ;  PMID:  22885615
• CCS52A2/FZR1, a cell cycle regulator, is an essential factor for shoot apical meristem maintenance in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-12-135 ;  PMID:  22873486
• CLE signaling systems during plant development and nematode infection.   DOI:  10.1093/pcp/pcs136 ;  PMID:  23045524
• Chemical synthesis of Arabidopsis CLV3 glycopeptide reveals the impact of hydroxyproline arabinosylation on peptide conformation and activity.   DOI:  10.1093/pcp/pcs174 ;  PMID:  23256149
• A set of Arabidopsis thaliana miRNAs involve shoot regeneration in vitro.   DOI:  10.4161/psb.23479 ;  PMID:  23333958
• Antagonistic peptide technology for functional dissection of CLV3/ESR genes in Arabidopsis.   DOI:  10.1104/pp.112.211029 ;  PMID:  23321419
• WUSCHEL protein movement and stem cell homeostasis.   DOI:  10.4161/psb.19793 ;  PMID:  22516820
• GUS activity for miR165a/166b, REV, and WUS/CLV3 in in vitro direct Arabidopsis thaliana shoot regeneration.   DOI:  10.1007/s00709-013-0503-1 ;  PMID:  23645346
• Individual amino acid residues in CLV3 peptide contribute to its stability in vitro.   DOI:  10.4161/psb.25344 ;  PMID:  23803748
• CLAVATA3-like genes are differentially expressed in grape vine (Vitis vinifera) tissues.   DOI:  10.1016/j.jplph.2013.04.013 ;  PMID:  23726469
• Phosphatidylserine synthase 1 is required for inflorescence meristem and organ development in Arabidopsis.   DOI:  10.1111/jipb.12045 ;  PMID:  23931744
• Incipient stem cell niche conversion in tissue culture: using a systems approach to probe early events in WUSCHEL-dependent conversion of lateral root primordia into shoot meristems.   DOI:  10.1111/tpj.12085 ;  PMID:  23181633
• A CLE-WOX signalling module regulates root meristem maintenance and vascular tissue development in rice.   DOI:  10.1093/jxb/ert301 ;  PMID:  24043854
• Evolutionarily conserved CLE peptide signaling in plant development, symbiosis, and parasitism.   DOI:  10.1016/j.pbi.2013.08.008 ;  PMID:  24035739
• The maize Gα gene COMPACT PLANT2 functions in CLAVATA signalling to control shoot meristem size.   DOI:  10.1038/nature12583 ;  PMID:  24025774
• Spatial expression of CLAVATA3 in the shoot apical meristem suggests it is not a stem cell marker in soybean.   DOI:  10.1093/jxb/ert341 ;  PMID:  24179098
• The sequence flanking the N-terminus of the CLV3 peptide is critical for its cleavage and activity in stem cell regulation in Arabidopsis.   DOI:  10.1186/1471-2229-13-225 ;  PMID:  24369789
• Histone H4R3 methylation catalyzed by SKB1/PRMT5 is required for maintaining shoot apical meristem.   DOI:  10.1371/journal.pone.0083258 ;  PMID:  24349476
• Stereoselective synthesis of Arabidopsis CLAVATA3 (CLV3) glycopeptide, unique protein post-translational modifications of secreted peptide hormone in plant.   DOI:  10.1039/c3ob41212a ;  PMID:  23912193
• Translational control of Arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h.   DOI:  10.1371/journal.pone.0095396 ;  PMID:  24736281
• A regulatory framework for shoot stem cell control integrating metabolic, transcriptional, and phytohormone signals.   DOI:  10.1016/j.devcel.2014.01.013 ;  PMID:  24576426
• The conflict between cell proliferation and expansion primarily affects stem organogenesis in Arabidopsis.   DOI:  10.1093/pcp/pcu131 ;  PMID:  25246492
• Tetralocular ovary and high silique width in yellow sarson lines of Brassica rapa (subspecies trilocularis) are due to a mutation in Bra034340 gene, a homologue of CLAVATA3 in Arabidopsis.   DOI:  10.1007/s00122-014-2382-z ;  PMID:  25205130
• Control of plant stem cell function by conserved interacting transcriptional regulators.   DOI:  10.1038/nature13853 ;  PMID:  25363783
• A plant U-box protein, PUB4, regulates asymmetric cell division and cell proliferation in the root meristem.   DOI:  10.1242/dev.113167 ;  PMID:  25605779
• Enhanced resistance to soybean cyst nematode Heterodera glycines in transgenic soybean by silencing putative CLE receptors.   DOI:  10.1111/pbi.12313 ;  PMID:  25581705
• Germline-transmitted genome editing in Arabidopsis thaliana Using TAL-effector-nucleases.   DOI:  10.1371/journal.pone.0121056 ;  PMID:  25822541
• Primary root protophloem differentiation requires balanced phosphatidylinositol-4,5-biphosphate levels and systemically affects root branching.   DOI:  10.1242/dev.118364 ;  PMID:  25813544
• Plant stem cell maintenance by transcriptional cross-regulation of related receptor kinases.   DOI:  10.1242/dev.119677 ;  PMID:  25758219
• Reevaluation of the CLV3-receptor interaction in the shoot apical meristem: dissection of the CLV3 signaling pathway from a direct ligand-binding point of view.   DOI:  10.1111/tpj.12817 ;  PMID:  25754504
• Mystery in genetics: PUB4 gives a clue to the complex mechanism of CLV signaling pathway in the shoot apical meristem.   DOI:  10.1080/15592324.2015.1028707 ;  PMID:  25898239
• Balanced cell proliferation and expansion is essential for flowering stem growth control.   DOI:  10.4161/15592324.2014.992755 ;  PMID:  25831425
• and CLE40-mediated columella stem cell homeostasis in Arabidopsis.   DOI:  10.1093/jxb/erv257 ;  PMID:  26019259
• An auxin responsive CLE gene regulates shoot apical meristem development in Arabidopsis.   DOI:  10.3389/fpls.2015.00295 ;  PMID:  25983737
• BAM 1 and RECEPTOR-LIKE PROTEIN KINASE 2 constitute a signaling pathway and modulate CLE peptide-triggered growth inhibition in Arabidopsis root.   DOI:  10.1111/nph.13520 ;  PMID:  26083273
• SQUINT promotes stem cell homeostasis and floral meristem termination in Arabidopsis through APETALA2 and CLAVATA signalling.   DOI:  10.1093/jxb/erv394 ;  PMID:  26269626
• Synergistic action of histone acetyltransferase GCN5 and receptor CLAVATA1 negatively affects ethylene responses in Arabidopsis thaliana.   DOI:  10.1093/jxb/erv503 ;  PMID:  26596766
• The CLAVATA signaling pathway mediating stem cell fate in shoot meristems requires Ca(2+) as a secondary cytosolic messenger.   DOI:  10.1111/tpj.13123 ;  PMID:  26756833
• Arabidopsis thaliana gonidialess A/Zuotin related factors (GlsA/ZRF) are essential for maintenance of meristem integrity.   DOI:  10.1007/s11103-016-0439-x ;  PMID:  26826012
• OBE3 and WUS Interaction in Shoot Meristem Stem Cell Regulation.   DOI:  10.1371/journal.pone.0155657 ;  PMID:  27196372
• Differential regulation of meristem size, morphology and organization by the ERECTA, CLAVATA and class III HD-ZIP pathways.   DOI:  10.1242/dev.129973 ;  PMID:  26989178
• FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis.   DOI:  10.1073/pnas.1602960113 ;  PMID:  27469166
• Threshold-dependent transcriptional discrimination underlies stem cell homeostasis.   DOI:  10.1073/pnas.1607669113 ;  PMID:  27671653
• Matching Patterns of Gene Expression to Mechanical Stiffness at Cell Resolution through Quantitative Tandem Epifluorescence and Nanoindentation.   DOI:  10.1104/pp.114.237115 ;  PMID:  24924426
• The ERECTA, CLAVATA and class III HD-ZIP Pathways Display Synergistic Interactions in Regulating Floral Meristem Activities.   DOI:  10.1371/journal.pone.0125408 ;  PMID:  25946150
• Beyond the meristems: similarities in the CLAVATA3 and INFLORESCENCE DEFICIENT IN ABSCISSION peptide mediated signalling pathways.   DOI:  10.1093/jxb/erv310 ;  PMID:  26105996
• A Molecular Framework for the Embryonic Initiation of Shoot Meristem Stem Cells.   DOI:  10.1016/j.devcel.2017.01.002 ;  PMID:  28171749
• Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components.   DOI:  10.1038/srep42450 ;  PMID:  28195159
• CLAVATA1 controls distinct signaling outputs that buffer shoot stem cell proliferation through a two-step transcriptional compensation loop.   DOI:  10.1371/journal.pgen.1006681 ;  PMID:  28355208
• Dynamic expression reveals a two-step patterning of WUS and CLV3 during axillary shoot meristem formation in Arabidopsis.   DOI:  10.1016/j.jplph.2017.03.017 ;  PMID:  28399422
• ARR12 promotes de novo shoot regeneration in Arabidopsis thaliana via activation of WUSCHEL expression.   DOI:  10.1111/jipb.12567 ;  PMID:  28681564
• ARGONAUTE10 Inhibits In Vitro Shoot Regeneration Via Repression of miR165/166 in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcx117 ;  PMID:  29016889
• A Collection of Mutants for CLE-Peptide-Encoding Genes in Arabidopsis Generated by CRISPR/Cas9-Mediated Gene Targeting.   DOI:  10.1093/pcp/pcx139 ;  PMID:  29036337
• Regulation of floral meristem activity through the interaction of AGAMOUS, SUPERMAN, and CLAVATA3 in Arabidopsis.   DOI:  10.1007/s00497-017-0315-0 ;  PMID:  29218596
• A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana.   DOI:  10.1186/s12915-018-0490-y ;  PMID:  29415713
• Impairment of Meristem Proliferation in Plants Lacking the Mitochondrial Protease AtFTSH4.   DOI:  10.3390/ijms19030853 ;  PMID:  29538317
• Expression of CLAVATA3 fusions indicates rapid intracellular processing and a role of ERAD.   DOI:  10.1016/j.plantsci.2018.03.020 ;  PMID:  29650159
• Cytokinin stabilizes WUSCHEL by acting on the protein domains required for nuclear enrichment and transcription.   DOI:  10.1371/journal.pgen.1007351 ;  PMID:  29659567
• A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis.   DOI:  10.1016/j.molp.2018.04.006 ;  PMID:  29730265
• SUPERMAN regulates floral whorl boundaries through control of auxin biosynthesis.   DOI:  10.15252/embj.201797499 ;  PMID:  29764982
• PORCUPINE regulates development in response to temperature through alternative splicing.   DOI:  10.1038/s41477-018-0176-z ;  PMID:  29988152
• HAIRY MERISTEM with WUSCHEL confines CLAVATA3 expression to the outer apical meristem layers.   DOI:  10.1126/science.aar8638 ;  PMID:  30072538
• The signaling peptide-encoding genes CLE16, CLE17 and CLE27 are dispensable for Arabidopsis shoot apical meristem activity.   DOI:  10.1371/journal.pone.0202595 ;  PMID:  30114285
• Dual CLAVATA3 Peptides in Arabidopsis Shoot Stem Cell Signaling.   DOI:  10.1007/s12374-017-0083-2 ;  PMID:  30310351
• Cargo-dependent and cell wall-associated xylem transport in Arabidopsis.   DOI:  10.1111/nph.15540 ;  PMID:  30317651
• Screening and identification of a non-peptide antagonist for the peptide hormone receptor in Arabidopsis.   DOI:  10.1038/s42003-019-0307-8 ;  PMID:  30793040
• Comprehensive Analyses of Nitric Oxide-Induced Plant Stem Cell-Related Genes in Arabidopsis thaliana.   DOI:  10.3390/genes10030190 ;  PMID:  30813477
• CLE-CLAVATA1 Signaling Pathway Modulates Lateral Root Development under Sulfur Deficiency.   DOI:  10.3390/plants8040103 ;  PMID:  31003469
• Evolution of buffering in a genetic circuit controlling plant stem cell proliferation.   DOI:  10.1038/s41588-019-0389-8 ;  PMID:  30988512
• An Aminoacyl tRNA Synthetase, OKI1, Is Required for Proper Shoot Meristem Size in Arabidopsis.   DOI:  10.1093/pcp/pcz153 ;  PMID:  31393575
• Redox-Mediated Endocytosis of a Receptor-Like Kinase during Distal Stem Cell Differentiation Depends on Its Tumor Necrosis Factor Receptor Domain.   DOI:  10.1104/pp.19.00616 ;  PMID:  31471454
• Transcriptional circuits in control of shoot stem cell homeostasis.   DOI:  10.1016/j.pbi.2019.10.004 ;  PMID:  31766002
• POLTERGEIST and POLTERGEIST-LIKE1 are essential for the maintenance of post-embryonic shoot and root apical meristems as revealed by a partial loss-of-function mutant allele of pll1 in Arabidopsis.   DOI:  10.1007/s13258-019-00894-8 ;  PMID:  31797316
• Local and Systemic Effects of Brassinosteroid Perception in Developing Phloem.   DOI:  10.1016/j.cub.2020.02.029 ;  PMID:  32220322
• Recent Advances in Arabidopsis CLE Peptide Signaling.   DOI:  10.1016/j.tplants.2020.04.014 ;  PMID:  32402660
• The Type-B Cytokinin Response Regulator ARR1 Inhibits Shoot Regeneration in an ARR12-Dependent Manner in Arabidopsis.   DOI:  10.1105/tpc.19.00022 ;  PMID:  32398274
• Integration of pluripotency pathways regulates stem cell maintenance in the Arabidopsis shoot meristem.   DOI:  10.1073/pnas.2015248117 ;  PMID:  32839309
• The Overlapping and Distinct Roles of HAM Family Genes in Arabidopsis Shoot Meristems.   DOI:  10.3389/fpls.2020.541968 ;  PMID:  33013964
• Morphological and Physiological Framework Underlying Plant Longevity in Arabidopsis thaliana.   DOI:  10.3389/fpls.2020.600726 ;  PMID:  33224176
• ERECTA family signaling constrains CLAVATA3 and WUSCHEL to the center of the shoot apical meristem.   DOI:  10.1242/dev.189753 ;  PMID:  33593817
• Stem integrity in Arabidopsis thaliana requires a load-bearing epidermis.   DOI:  10.1242/dev.198028 ;  PMID:  33637612
• Conserved and differentiated functions of CIK receptor kinases in modulating stem cell signaling in Arabidopsis.   DOI:  10.1016/j.molp.2021.04.001 ;  PMID:  33823234
• Receptor-like cytoplasmic kinase MAZZA mediates developmental processes with CLAVATA1 family receptors in Arabidopsis.   DOI:  10.1093/jxb/erab183 ;  PMID:  33909893
• CLAVATA3, a plant peptide controlling stem cell fate in the meristem.   DOI:  10.1016/j.peptides.2021.170579 ;  PMID:  34033873
• The Cell Fate Controlling CLE40 Peptide Requires CNGCs to Trigger Highly Localized Ca2+ Transients in Arabidopsis thaliana Root Meristems.   DOI:  10.1093/pcp/pcab079 ;  PMID:  34059877
• Expression of KNUCKLES in the Stem Cell Domain Is Required for Its Function in the Control of Floral Meristem Activity in Arabidopsis.   DOI:  10.3389/fpls.2021.704351 ;  PMID:  34367223
• Knox homologs shoot meristemless (STM) and KNAT6 are epistatic to CLAVATA3 (CLV3) during shoot meristem development in Arabidopsis thaliana.   DOI:  10.1007/s11033-021-06622-4 ;  PMID:  34417947
• Robust control of floral meristem determinacy by position-specific multifunctions of KNUCKLES.   DOI:  10.1073/pnas.2102826118 ;  PMID:  34462349
• Cadmium affects cell niches maintenance in Arabidopsis thaliana post-embryonic shoot and root apical meristem by altering the expression of WUS/WOX homolog genes and cytokinin accumulation.   DOI:  10.1016/j.plaphy.2021.09.014 ;  PMID:  34530323
• Control of Arabidopsis shoot stem cell homeostasis by two antagonistic CLE peptide signalling pathways.   DOI:  10.7554/eLife.70934 ;  PMID:  34643181
• CLAVATA3 mediated simultaneous control of transcriptional and post-translational processes provides robustness to the WUSCHEL gradient.   DOI:  10.1038/s41467-021-26586-0 ;  PMID:  34737298
• CLE peptides: critical regulators for stem cell maintenance in plants.   DOI:  10.1007/s00425-021-03791-1 ;  PMID:  34841457
• Receptor-like cytoplasmic kinases PBL34/35/36 are required for CLE peptide-mediated signaling to maintain shoot apical meristem and root apical meristem homeostasis in Arabidopsis.   DOI:  10.1093/plcell/koab315 ;  PMID:  34935965
• Control of Root Stem Cell Differentiation and Lateral Root Emergence by CLE16/17 Peptides in Arabidopsis.   DOI:  10.3389/fpls.2022.869888 ;  PMID:  35519820
• Evolution of meristem zonation by CLE gene duplication in land plants.   DOI:  10.1038/s41477-022-01199-7 ;  PMID:  35854003
• De novo stem cell establishment in meristems requires repression of organ boundary cell fate.   DOI:  10.1093/plcell/koac269 ;  PMID:  36029254
• Interactive CLV3, CLE16 and CLE17 signaling mediates stem cell homeostasis in the Arabidopsis shoot apical meristem.   DOI:  10.1242/dev.200787 ;  PMID:  36111520
• Genome-wide identification and comparative analysis of CLE family in rapeseed and its diploid progenitors.   DOI:  10.3389/fpls.2022.998082 ;  PMID:  36340404
• CLE3 and its homologs share overlapping functions in the modulation of lateral root formation through CLV1 and BAM1 in Arabidopsis thaliana.   DOI:  10.1111/tpj.16103 ;  PMID:  36628476
• A phosphoinositide hub connects CLE peptide signaling and polar auxin efflux regulation.   DOI:  10.1038/s41467-023-36200-0 ;  PMID:  36702874
• pH-dependent CLE peptide perception permits phloem differentiation in Arabidopsis roots.   DOI:  10.1016/j.cub.2022.12.056 ;  PMID:  36693368
• The AtERF19 gene regulates meristem activity and flower organ size in plants.   DOI:  10.1111/tpj.16196 ;  PMID:  36932949
• How flower development genes were identified using forward genetic screens in Arabidopsis thaliana.   DOI:  10.1093/genetics/iyad102 ;  PMID:  37294732
• Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity.   DOI:  10.1126/science.289.5479.617 ;  PMID:  10915624

Sequences: