Gene Details:
Functional Descriptions:
- A gene encoding WUSCHEL-related homeobox transcription factor, named as WOX-SPINE1 (WS1), was identified as the candidate gene controlling the spine development in lettuce, and its function on spines was verified.
- A CACTA transposon was found to be inserted into the first exon of the WS1 allele, knocking out its function and leading to the lack of spines in cultivated lettuce.
- All lettuce cultivars investigated have the nonfunctional WS1 gene, and a selection sweep was found at the WS1 locus, suggesting its important role in lettuce domestication.
- The expression levels of WS1 were associated with the density of spines among different accessions of wild lettuce. At least two independent loss-of-function mutations in the WS1 gene caused the loss of spines in wild lettuce.
Function-related keywords:
Literature:
- A WOX homolog disrupted by a transposon led to the loss of spines and contributed to the domestication of lettuce. DOI: 10.1111/nph.19738 ; PMID: 38584520
Related News:
Gene Resources:
- NCBI ID: OQ858569.1
- UniProt accessions: A0AA49X5L5
Orthologs:
Sequences:
- CDS Sequence:
- Protein Sequence: