FvJAZ12

Gene Details:

A cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry (Fragaria vesca).
FvJAZ12 acts to regulate flavor metabolism and defense response, and was found to be the target of FvMPK6, a mitogen-activated protein kinase that is capable of responding to multiple signal stimuli.
FvMPK6 phosphorylates FvJAZ12 at the amino acid residues S179 and T183 adjacent to the PY residues, thereby attenuating its nuclear accumulation and relieving its repression for FvMYC2, which acts to control the expression of lipoxygenase 3 (FvLOX3), an important gene involved in JA biosynthesis and a diverse array of cellular metabolisms.
Our results uncover a previously unknown aspect of JAZ signal transduction and elucidate a complete signaling cascade that links multiple primary signal inputs with fruit trait development, that is, JA and multiple environmental stimuli-FvMPK6-FvJAZ12-FvMYC2-FvLOX3 (lipoxygenase 3)-flavor metabolism, antipathogen.