Gene Details:

  • Gene ID:
  • Gene Symbol: NtGNL1a
  • Gene Name: GNOM-LIKE protein1a
  • Genome:
  • Species: Nicotiana tabacum

Functional Descriptions:

  • NtGNL1a ARF-GEF acts in endocytosis in tobacco cells.
  • In concert with this finding, we demonstrate that the point mutation in the Sec7 domain of the GNOM-LIKE protein1a (NtGNL1a) confers intracellular trafficking pathway-specific BFA resistance.
  • The internalization of FM 4–64 and trafficking of PIN-FORMED1 (PIN1) auxin efflux carrier in BY-2 tobacco cells were studied to reveal the function of the ARF-GEF NtGNL1a in these.
  • Our observations uncovered the role of NtGNL1a in endocytosis, including endocytosis of PM proteins (as PIN1 auxin efflux carrier).
  • Conversion of BFA-resistant NtGNL1a ARF-GEF to its BFA-sensitive form by site-directed mutagenesis uncovers its role in the endocytosis.

Literature:

Gene Resources:

Orthologs:

Sequences:

  • CDS Sequence:
  • Protein Sequence: