Gene Details:

• Gene ID: Niben101Scf07608g00007
• Gene Symbol: NbCML30
• Gene Name: calmodulin-like protein 30
• Genome:
• Species: Nicotiana benthamiana

Functional Descriptions:

• Tobacco mosaic virus hijacks its coat protein-interacting protein IP-L to inhibit NbCML30, a calmodulin-like protein, to enhance its infection.
• NbCML30, which lacks the EF-hand conserved domain and cannot bind to Ca2+, was located in the cytoplasm and nucleus and was downregulated by TMV infection.
• NbCML30 silencing promoted TMV infection, while its overexpression inhibited TMV infection by activating Ca2+-dependent oxidative stress in plants.
• NbCML30-mediated resistance to TMV mainly depends on IP-L regulation as the facilitation of TMV infection by silencing NbCML30 was canceled by co-silencing NbCML30 and IP-L.
• TMV CP manipulates IP-L to inhibit NbCML30, influencing its Ca2+-dependent role in the oxidative stress response.

Function-related keywords:

• resistance ,  stress ,  oxidative-stress ,  nucleus ,  oxidative ,  cytoplasm ,  stress-response ,  virus ,  protein

Literature:

• Tobacco mosaic virus hijacks its coat protein-interacting protein IP-L to inhibit NbCML30, a calmodulin-like protein, to enhance its infection.   DOI:  10.1111/tpj.15972 ;  PMID:  36087000

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Orthologs:

Sequences:

• CDS Sequence:
• Protein Sequence: