Gene Details:

• Gene ID:
• Gene Symbol: MtTdp1α
• Gene Name: tyrosyl-DNA phosphodiesterase 1
• Genome:
• Species: Medicago truncatula

Functional Descriptions:

• An intron-spliced hairpin RNA approach was used for the targeted silencing of the MtTdp1α gene encoding the αisoform of tyrosyl-DNA phosphodiesterase 1 in Medicago truncatula Gaertn.
• RNA-Seq analysis, carried out in the MtTdp1α-depleted plants, revealed different levels of transcriptional modulation (up- and down-regulation, alternative splicing, activation of alternative promoter) in genes involved in DNA damage sensing, DNA repair, and chromatin remodelling.
• It is suggested that the MtTdp1α gene has new, previously undetected roles in maintaining genome integrity. Up-regulation of senescence-associated genes and telomere shortening were observed.
• Impaired ribosome biogenesis indicated that the MtTdp1α gene is required for the nucleolar function.In agreement with the RNA-Seq data, transmission electron microscopy detected an altered nucleolar architecture in the MtTdp1α-depleted cells.

Function-related keywords:

• senescence ,  architecture ,  dna-repair

Literature:

• RNA-Seq analysis discloses early senescence and nucleolar dysfunction triggered by Tdp1α depletion in Medicago truncatula.   DOI:  10.1093/jxb/ert063 ;  PMID:  23467834

Related News:

Gene Resources:

• NCBI ID: XM_003622639
• UniProt accessions:

Orthologs:

Sequences:

• CDS Sequence:
• Protein Sequence: